Acute lymphoblastic leukaemia in a child with systemic lupus erythematosus.
Lupus
; 21(8): 910-3, 2012 Jul.
Article
in En
| MEDLINE
| ID: mdl-22331193
ABSTRACT
Haematological involvement of systemic lupus erythematosus (SLE) - which ranges from the well-described haemolytic anaemia to macrophage activation syndrome - has a large impact on both morbidity and mortality. On the other hand, association between haematological malignities and SLE - in terms of pathophysiology and molecular genetics - is an obscure entity which has not been clarified evidently to date. Herein, we present a six-year-old female with the diagnosis of SLE who developed acute lymphoblastic leukaemia following a period of myelodysplasia. It could possibly be coincidental; however, persistent cytopenia, prominent dysplasia on bone marrow smears and azathioprine treatment may be considered as possible triggers for the development of leukaemia in the present case.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Myelodysplastic Syndromes
/
Precursor Cell Lymphoblastic Leukemia-Lymphoma
/
Lupus Erythematosus, Systemic
Limits:
Child
/
Female
/
Humans
Language:
En
Journal:
Lupus
Journal subject:
REUMATOLOGIA
Year:
2012
Document type:
Article
Affiliation country:
Turkey