New losartan-hydrocaffeic acid hybrids as antihypertensive-antioxidant dual drugs: Ester, amide and amine linkers.
Eur J Med Chem
; 50: 90-101, 2012 Apr.
Article
in En
| MEDLINE
| ID: mdl-22336384
ABSTRACT
We report new examples of a series of losartan-hydrocaffeic hybrids that bear novel ester, amide and amine linkers. These compounds were made by linking hydrocaffeic acid to the side chain of losartan at the C-5 position of the imidazole ring through different strategies. Experiments performed in cultured cells demonstrate that these new hybrids retain the ability to block the angiotensin II effect and have increased antioxidant ability. Most of them reduced arterial pressure in rats better or as much as losartan.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Caffeic Acids
/
Losartan
/
Antihypertensive Agents
/
Antioxidants
Limits:
Animals
Language:
En
Journal:
Eur J Med Chem
Year:
2012
Document type:
Article
Affiliation country:
Spain