Implications of promiscuous Pim-1 kinase fragment inhibitor hydrophobic interactions for fragment-based drug design.

Good, Andrew C; Liu, Jinyu; Hirth, Bradford; Asmussen, Gary; Xiang, Yibin; Biemann, Hans-Peter; Bishop, Kimberly A; Fremgen, Trisha; Fitzgerald, Maria; Gladysheva, Tatiana; Jain, Annuradha; Jancsics, Katherine; Metz, Markus; Papoulis, Andrew; Skerlj, Renato; Stepp, J David; Wei, Ronnie R

Good, Andrew C; Liu, Jinyu; Hirth, Bradford; Asmussen, Gary; Xiang, Yibin; Biemann, Hans-Peter; Bishop, Kimberly A; Fremgen, Trisha; Fitzgerald, Maria; Gladysheva, Tatiana; Jain, Annuradha; Jancsics, Katherine; Metz, Markus; Papoulis, Andrew; Skerlj, Renato; Stepp, J David; Wei, Ronnie R.

Affiliation

Good AC; Department of Medicinal Chemistry, Genzyme Corp., 153 Second Avenue, Waltham, Massachusetts 02451, United States. andrew.good@genzyme.com

J Med Chem ; 55(6): 2641-8, 2012 Mar 22.

Article in En | MEDLINE | ID: mdl-22339127

Subject(s)

Enzyme Inhibitors/chemistry; Models, Molecular; Proto-Oncogene Proteins c-pim-1/antagonists & inhibitors; Proto-Oncogene Proteins c-pim-1/chemistry; Crystallography, X-Ray; Drug Design; Hydrophobic and Hydrophilic Interactions; Molecular Structure; Protein Binding; Stereoisomerism; Structure-Activity Relationship

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Models, Molecular / Enzyme Inhibitors / Proto-Oncogene Proteins c-pim-1 Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2012 Document type: Article Affiliation country: United States

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