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Rapid T-cell-based immunodiagnosis of tuberculous peritonitis in a peritoneal dialysis patient.
Müller, Catharina; Puttinger, Heidemarie; Winnicki, Wolfgang; Winkler, Heide-Maria; Vychytil, Andreas; Winkler, Stefan.
Affiliation
  • Müller C; Department of Internal Medicine I, Division of Infectious Diseases and Tropical Medicine, Medical University of Vienna, Austria.
Scand J Urol Nephrol ; 46(4): 314-6, 2012 Aug.
Article in En | MEDLINE | ID: mdl-22339389
Tuberculous peritonitis is a rare complication during peritoneal dialysis (PD). This report presents the case of a patient with clinical signs and symptoms indicative of bacterial peritonitis, but without culture growth of conventional bacteria or fungi. Cytokine flow cytometry after overnight stimulation of cells from peripheral blood and the peritoneal dialysate with Mycobacterium tuberculosis (MTB)-specific antigens revealed a 40-fold increase in MTB-specific CD4 + T cells expressing interferon-γ (IFN-γ) in peritoneal fluid compared with blood, which was indicative of active tuberculosis (TB). The presence of TB was later confirmed by polymerase chain reaction and growth of MTB in culture of the dialysate. The case illustrates the usefulness of MTB-specific immunodiagnosis for the rapid identification of peritoneal TB in PD patients.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peritonitis, Tuberculous / CD4-Positive T-Lymphocytes / Peritoneal Dialysis, Continuous Ambulatory Type of study: Etiology_studies Limits: Adult / Female / Humans Language: En Journal: Scand J Urol Nephrol Year: 2012 Document type: Article Affiliation country: Austria Country of publication: United kingdom

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peritonitis, Tuberculous / CD4-Positive T-Lymphocytes / Peritoneal Dialysis, Continuous Ambulatory Type of study: Etiology_studies Limits: Adult / Female / Humans Language: En Journal: Scand J Urol Nephrol Year: 2012 Document type: Article Affiliation country: Austria Country of publication: United kingdom