Spatial parkin translocation and degradation of damaged mitochondria via mitophagy in live cortical neurons.

Cai, Qian; Zakaria, Hesham Mostafa; Simone, Anthony; Sheng, Zu-Hang

Cai, Qian; Zakaria, Hesham Mostafa; Simone, Anthony; Sheng, Zu-Hang.

Affiliation

Cai Q; Synaptic Functions Section, Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Room 2B-215, 35 Convent Drive, Bethesda, MD 20892-3706, USA. cai@biology.rutgers.edu

Curr Biol ; 22(6): 545-52, 2012 Mar 20.

Article in En | MEDLINE | ID: mdl-22342752

Subject(s)

Neurons/metabolism; Ubiquitin-Protein Ligases/metabolism; Animals; Autophagy; Biological Transport, Active/drug effects; Carbonyl Cyanide m-Chlorophenyl Hydrazone/toxicity; Cells, Cultured; Cerebral Cortex/cytology; Cerebral Cortex/metabolism; Gene Knockdown Techniques; Lysosomes/metabolism; Membrane Potential, Mitochondrial; Mice; Mice, Transgenic; Mitochondria/metabolism; Neurons/drug effects; RNA, Small Interfering/genetics; Recombinant Fusion Proteins/genetics; Recombinant Fusion Proteins/metabolism; Ubiquitin-Protein Ligases/antagonists & inhibitors; Ubiquitin-Protein Ligases/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ubiquitin-Protein Ligases / Neurons Limits: Animals Language: En Journal: Curr Biol Journal subject: BIOLOGIA Year: 2012 Document type: Article Affiliation country: United States

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