Non-clinical safety assessment and toxicokinetics of voriconazole and anidulafungin in the juvenile rat: a combination study design in support of a Paediatric Investigation Plan.

Cross, David M; Chmielewski, Gary; Lewis, Elise M; Liu, Lei; Modesitt, Michael S; Ripp, Sharon L; Sawaryn, Christopher M; Bowman, Christopher J

Cross, David M; Chmielewski, Gary; Lewis, Elise M; Liu, Lei; Modesitt, Michael S; Ripp, Sharon L; Sawaryn, Christopher M; Bowman, Christopher J.

Affiliation

Cross DM; Pfizer Ltd., Drug Safety Research & Development, Sandwich, UK.

Regul Toxicol Pharmacol ; 63(1): 29-39, 2012 Jun.

Article in En | MEDLINE | ID: mdl-22343256

Subject(s)

Antifungal Agents/pharmacokinetics; Antifungal Agents/toxicity; Echinocandins/pharmacokinetics; Echinocandins/toxicity; Pyrimidines/pharmacokinetics; Pyrimidines/toxicity; Triazoles/pharmacokinetics; Triazoles/toxicity; Administration, Oral; Anidulafungin; Animals; Antifungal Agents/administration & dosage; Area Under Curve; Drug Combinations; Drug Evaluation, Preclinical/methods; Echinocandins/administration & dosage; Female; Injections, Subcutaneous; Male; Pyrimidines/administration & dosage; Rats; Rats, Inbred F344; Research Design; Sex Factors; Toxicity Tests/methods; Triazoles/administration & dosage; Voriconazole

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / Triazoles / Echinocandins / Antifungal Agents Type of study: Prognostic_studies Limits: Animals Language: En Journal: Regul Toxicol Pharmacol Year: 2012 Document type: Article Affiliation country: United kingdom Country of publication: Netherlands

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