Administration of fasudil, a ROCK inhibitor, attenuates disease in lupus-prone NZB/W F1 female mice.

Stirzaker, R A; Biswas, P S; Gupta, S; Song, L; Bhagat, G; Pernis, A B

Stirzaker, R A; Biswas, P S; Gupta, S; Song, L; Bhagat, G; Pernis, A B.

Affiliation

Stirzaker RA; Autoimmunity and Inflammation Research Program, Hospital for Special Surgery, New York, USA.

Lupus ; 21(6): 656-61, 2012 May.

Article in En | MEDLINE | ID: mdl-22345122

Subject(s)

1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine/analogs & derivatives; Disease Models, Animal; Enzyme Inhibitors/therapeutic use; Lupus Erythematosus, Systemic/prevention & control; rho-Associated Kinases/antagonists & inhibitors; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine/administration & dosage; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine/pharmacology; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine/therapeutic use; Administration, Oral; Animals; Antigen-Antibody Complex/blood; Autoantibodies/blood; Enzyme Inhibitors/administration & dosage; Enzyme Inhibitors/pharmacology; Female; Glomerulonephritis/prevention & control; Lupus Erythematosus, Systemic/immunology; Lupus Erythematosus, Systemic/mortality; Lymphocyte Subsets/drug effects; Lymphocyte Subsets/pathology; Mice; Mice, Inbred NZB; Mice, Mutant Strains; Proteinuria/prevention & control

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine / Disease Models, Animal / Enzyme Inhibitors / Rho-Associated Kinases / Lupus Erythematosus, Systemic Limits: Animals Language: En Journal: Lupus Journal subject: REUMATOLOGIA Year: 2012 Document type: Article Affiliation country: United States Country of publication: United kingdom

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