Germline deletion of Igh 3' regulatory region elements hs 5, 6, 7 (hs5-7) affects B cell-specific regulation, rearrangement, and insulation of the Igh locus.

Volpi, Sabrina A; Verma-Gaur, Jiyoti; Hassan, Rabih; Ju, Zhongliang; Roa, Sergio; Chatterjee, Sanjukta; Werling, Uwe; Hou, Harry; Will, Britta; Steidl, Ulrich; Scharff, Matthew; Edelman, Winfried; Feeney, Ann J; Birshtein, Barbara K

Volpi, Sabrina A; Verma-Gaur, Jiyoti; Hassan, Rabih; Ju, Zhongliang; Roa, Sergio; Chatterjee, Sanjukta; Werling, Uwe; Hou, Harry; Will, Britta; Steidl, Ulrich; Scharff, Matthew; Edelman, Winfried; Feeney, Ann J; Birshtein, Barbara K.

Affiliation

Volpi SA; Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

J Immunol ; 188(6): 2556-66, 2012 Mar 15.

Article in En | MEDLINE | ID: mdl-22345664

Subject(s)

B-Lymphocytes/immunology; Genes, Immunoglobulin Heavy Chain/genetics; Germ-Line Mutation; Regulatory Sequences, Nucleic Acid/immunology; Animals; CCCTC-Binding Factor; Flow Cytometry; Genes, Immunoglobulin Heavy Chain/immunology; Immunoglobulin Class Switching/genetics; Immunoglobulin Class Switching/immunology; In Situ Hybridization, Fluorescence; Mice; Mice, Inbred C57BL; Mice, Knockout; Polymerase Chain Reaction; Repressor Proteins/genetics; Repressor Proteins/immunology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: B-Lymphocytes / Regulatory Sequences, Nucleic Acid / Germ-Line Mutation / Genes, Immunoglobulin Heavy Chain Limits: Animals Language: En Journal: J Immunol Year: 2012 Document type: Article Affiliation country: United States Country of publication: United States

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