Immunosuppressants reduce venous thrombosis relapse in Behçet's disease.
Arthritis Rheum
; 64(8): 2753-60, 2012 Aug.
Article
in En
| MEDLINE
| ID: mdl-22354392
ABSTRACT
OBJECTIVE:
To investigate and describe the long-term outcome of venous thrombosis in patients with Behçet's disease (BD).METHODS:
In a retrospective cohort of 807 BD patients, a reported 296 patients (36.7%) (73.3% male, median age 30 years [interquartile range 24-36 years]) met the international classification criteria for BD and had venous thrombosis. We assessed factors associated with thrombosis relapse and mortality.RESULTS:
There were a total of 586 venous thrombosis events, including 560 cases of deep thrombosis and 26 cases of superficial thrombosis. Deep venous thrombosis events included 323 cases of limb thrombosis (55.1%), 77 cases of cerebral venous thrombosis (13.1%), 57 cases of pulmonary embolism (9.7%), 63 cases of vena cava lesions (10.7%), 14 cases of Budd-Chiari syndrome (2.4%), and 13 cases of cervical vein thrombosis (2.2%). One hundred of 296 patients (33.8%) experienced at least 1 venous thrombosis relapse. The mortality rate was 6.4% (19 of 296 patients) after a median followup of 4.75 years (interquartile range 2-7 years). In univariate analysis, death was associated with cardiac involvement (P = 0.026) and Budd-Chiari syndrome (P = 0.004). In multivariate analysis, the use of immunosuppressive agents was found to prevent relapse of venous thrombosis (hazard ratio 0.27 [95% confidence interval 0.14-0.52], P = 0.00021), and there was a trend toward prevention of relapse with the use of glucocorticoids (hazard ratio 0.62 [95% confidence interval 0.40-0.97], P = 0.058).CONCLUSION:
Immunosuppressive agents significantly reduce venous thrombosis relapse in BD.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Behcet Syndrome
/
Venous Thrombosis
/
Immunosuppressive Agents
Type of study:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
En
Journal:
Arthritis Rheum
Year:
2012
Document type:
Article
Affiliation country:
France