Pharmacokinetics, tissue distribution, and plasma protein binding study of platinum originating from dicycloplatin, a novel antitumor supramolecule, in rats and dogs by ICP-MS.

Zhao, Di; Zhang, Yongjie; Xu, Chunxiang; Dong, Can; Lin, Hui; Zhang, Lingli; Li, Cuiyun; Ren, Shuangxia; Wang, Xin; Yang, Shuoye; Han, Deen; Chen, Xijing

Zhao, Di; Zhang, Yongjie; Xu, Chunxiang; Dong, Can; Lin, Hui; Zhang, Lingli; Li, Cuiyun; Ren, Shuangxia; Wang, Xin; Yang, Shuoye; Han, Deen; Chen, Xijing.

Affiliation

Zhao D; Center of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, Jiangsu, People's Republic of China.

Biol Trace Elem Res ; 148(2): 203-8, 2012 Aug.

Article in En | MEDLINE | ID: mdl-22367705

Subject(s)

Antineoplastic Agents/pharmacokinetics; Glutamates/pharmacokinetics; Mass Spectrometry/methods; Organoplatinum Compounds/pharmacokinetics; Platinum/pharmacokinetics; Animals; Antineoplastic Agents/administration & dosage; Carboplatin/pharmacology; Dogs; Drug Combinations; Drug Screening Assays, Antitumor/methods; Glutamates/administration & dosage; Half-Life; Injections, Intravenous; Male; Organoplatinum Compounds/administration & dosage; Platinum/blood; Prostate/metabolism; Protein Binding; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity; Testis/metabolism; Time Factors; Tissue Distribution

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Organoplatinum Compounds / Platinum / Mass Spectrometry / Glutamates / Antineoplastic Agents Type of study: Diagnostic_studies Limits: Animals Language: En Journal: Biol Trace Elem Res Year: 2012 Document type: Article

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