Novel, druglike 1,7-disubstituted 2,3,4,5-tetrahydro-1H-benzo[b]azepine-based selective inhibitors of human neuronal nitric oxide synthase (nNOS).

Annedi, Subhash C; Ramnauth, Jailall; Cossette, Michele; Maddaford, Shawn P; Dove, Peter; Rakhit, Suman; Andrews, John S; Porreca, Frank

Annedi, Subhash C; Ramnauth, Jailall; Cossette, Michele; Maddaford, Shawn P; Dove, Peter; Rakhit, Suman; Andrews, John S; Porreca, Frank.

Affiliation

Annedi SC; NeurAxon Inc., 2395 Speakman Drive, Suite # 1001, Mississauga, ON, Canada L5K 1B3. sannedi@neuraxon.com

Bioorg Med Chem Lett ; 22(7): 2510-3, 2012 Apr 01.

Article in En | MEDLINE | ID: mdl-22370270

Subject(s)

Analgesics/chemical synthesis; Benzazepines/chemical synthesis; Enzyme Inhibitors/chemical synthesis; Neuralgia/drug therapy; Nitric Oxide Synthase Type I/antagonists & inhibitors; Analgesics/administration & dosage; Analgesics/therapeutic use; Animals; Benzazepines/administration & dosage; Benzazepines/therapeutic use; Enzyme Inhibitors/administration & dosage; Enzyme Inhibitors/therapeutic use; High-Throughput Screening Assays; Humans; Mice; Neuralgia/enzymology; Neuralgia/physiopathology; Nitric Oxide Synthase Type I/metabolism; Nitric Oxide Synthase Type II/metabolism; Nitric Oxide Synthase Type III/metabolism; Recombinant Proteins/metabolism; Spinal Nerves/drug effects; Spinal Nerves/enzymology; Spinal Nerves/physiopathology; Stereoisomerism; Structure-Activity Relationship

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzazepines / Enzyme Inhibitors / Nitric Oxide Synthase Type I / Analgesics / Neuralgia Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2012 Document type: Article

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