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Verrulactones A and B, new inhibitors of Staphylococcus aureus enoyl-ACP reductase produced by Penicillium verruculosum F375.
Kim, Nyung; Sohn, Mi-Jin; Kim, Chang-Jin; Kwon, Ho Jeong; Kim, Won-Gon.
Affiliation
  • Kim N; Korea Research Institute of Bioscience and Biotechnology, PO Box 115, Yusong, Daejeon 305-806, Republic of Korea.
Bioorg Med Chem Lett ; 22(7): 2503-6, 2012 Apr 01.
Article in En | MEDLINE | ID: mdl-22377515
ABSTRACT
New dimeric compounds of alternariol class, verrulactones A and B, were isolated from a culture broth of the fungal strain Penicillium verruculosum F375 and their structure were established by various spectral analysis. Verrulactones A and B strongly inhibited Staphylococcus aureus enoyl-ACP reductase with IC(50) of 0.92 and 1.41 µM, respectively, and also showed antibacterial activity against S. aureus and MRSA with MICs of 8 and 16 µg/mL, respectively.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Penicillium / Enzyme Inhibitors / Enoyl-(Acyl-Carrier-Protein) Reductase (NADH) / Methicillin-Resistant Staphylococcus aureus / Heterocyclic Compounds, 4 or More Rings / Lactones Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2012 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Penicillium / Enzyme Inhibitors / Enoyl-(Acyl-Carrier-Protein) Reductase (NADH) / Methicillin-Resistant Staphylococcus aureus / Heterocyclic Compounds, 4 or More Rings / Lactones Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2012 Document type: Article