Verrulactones A and B, new inhibitors of Staphylococcus aureus enoyl-ACP reductase produced by Penicillium verruculosum F375.
Bioorg Med Chem Lett
; 22(7): 2503-6, 2012 Apr 01.
Article
in En
| MEDLINE
| ID: mdl-22377515
ABSTRACT
New dimeric compounds of alternariol class, verrulactones A and B, were isolated from a culture broth of the fungal strain Penicillium verruculosum F375 and their structure were established by various spectral analysis. Verrulactones A and B strongly inhibited Staphylococcus aureus enoyl-ACP reductase with IC(50) of 0.92 and 1.41 µM, respectively, and also showed antibacterial activity against S. aureus and MRSA with MICs of 8 and 16 µg/mL, respectively.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Penicillium
/
Enzyme Inhibitors
/
Enoyl-(Acyl-Carrier-Protein) Reductase (NADH)
/
Methicillin-Resistant Staphylococcus aureus
/
Heterocyclic Compounds, 4 or More Rings
/
Lactones
Language:
En
Journal:
Bioorg Med Chem Lett
Journal subject:
BIOQUIMICA
/
QUIMICA
Year:
2012
Document type:
Article