Systematic evaluation of the metabolic to mitogenic potency ratio for B10-substituted insulin analogues.

Glendorf, Tine; Knudsen, Louise; Stidsen, Carsten E; Hansen, Bo F; Hegelund, Anne Charlotte; Sørensen, Anders R; Nishimura, Erica; Kjeldsen, Thomas

Glendorf, Tine; Knudsen, Louise; Stidsen, Carsten E; Hansen, Bo F; Hegelund, Anne Charlotte; Sørensen, Anders R; Nishimura, Erica; Kjeldsen, Thomas.

Affiliation

Glendorf T; Diabetes Research Unit, Novo Nordisk A/S, Maaloev, Denmark. tgle@novonordisk.com

PLoS One ; 7(2): e29198, 2012.

Article in En | MEDLINE | ID: mdl-22383948

Subject(s)

Insulin/analogs & derivatives; Insulin/chemistry; Amino Acid Substitution; Animals; Antigens, CD/chemistry; Biochemistry/methods; Cell Line; Cricetinae; DNA/chemistry; Humans; Inhibitory Concentration 50; Protein Binding; Protein Conformation; Protein Isoforms; Rats; Receptor, IGF Type 1/chemistry; Receptor, Insulin/chemistry; Receptor, Insulin/metabolism; Saccharomyces cerevisiae/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Insulin Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2012 Document type: Article Affiliation country: Denmark Country of publication: United States

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