Discovery of thiadiazole amides as potent, S1P3-sparing agonists of sphingosine-1-phosphate 1 (S1P1) receptor.

Xu, Heng; Zhang, Haibo; Luan, Linbo; Xu, Yan; Li, Chengyong; Wang, Yonghui; Han, Fangbin; Yang, Ting; Ren, Feng; Xiang, Jia-Ning; Elliott, John D; Zhao, Yonggang; Guo, Taylor B; Lu, Hongtao; Zhang, Wei; Hirst, David; Lindon, Matthew; Lin, Xichen

Xu, Heng; Zhang, Haibo; Luan, Linbo; Xu, Yan; Li, Chengyong; Wang, Yonghui; Han, Fangbin; Yang, Ting; Ren, Feng; Xiang, Jia-Ning; Elliott, John D; Zhao, Yonggang; Guo, Taylor B; Lu, Hongtao; Zhang, Wei; Hirst, David; Lindon, Matthew; Lin, Xichen.

Affiliation

Xu H; GlaxoSmithKline Pharmaceuticals, R&D China, 898 Halei Road, Zhangjiang Hi-Tech Park, Pudong, Shanghai 201023, China.

Bioorg Med Chem Lett ; 22(7): 2456-9, 2012 Apr 01.

Article in En | MEDLINE | ID: mdl-22386243

Subject(s)

Amides/chemistry; Immunologic Factors/chemistry; Receptors, Lysosphingolipid/agonists; Thiadiazoles/chemistry; Amides/pharmacology; Animals; Drug Discovery; High-Throughput Screening Assays; Humans; Immunologic Factors/pharmacology; Lymphocytes/drug effects; Lymphocytes/immunology; Mice; Receptors, Lysosphingolipid/chemistry; Small Molecule Libraries/chemistry; Small Molecule Libraries/pharmacology; Structure-Activity Relationship; Thiadiazoles/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thiadiazoles / Receptors, Lysosphingolipid / Amides / Immunologic Factors Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2012 Document type: Article Affiliation country: China Country of publication: United kingdom

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