Afferent drive elicits ongoing pain in a model of advanced osteoarthritis.

Okun, Alec; Liu, Ping; Davis, Peg; Ren, Jiyang; Remeniuk, Bethany; Brion, Triza; Ossipov, Michael H; Xie, Jennifer; Dussor, Gregory O; King, Tamara; Porreca, Frank

Okun, Alec; Liu, Ping; Davis, Peg; Ren, Jiyang; Remeniuk, Bethany; Brion, Triza; Ossipov, Michael H; Xie, Jennifer; Dussor, Gregory O; King, Tamara; Porreca, Frank.

Affiliation

Okun A; Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ 85724, USA Institute of Clinical Pharmacology, Qilu Hospital of Shandong University, Jinan 250012, China.

Pain ; 153(4): 924-933, 2012 Apr.

Article in En | MEDLINE | ID: mdl-22387095

Subject(s)

Disease Models, Animal; Neurons, Afferent/physiology; Osteoarthritis/physiopathology; Pain/physiopathology; Severity of Illness Index; Afferent Pathways/drug effects; Afferent Pathways/physiopathology; Animals; Dose-Response Relationship, Drug; Injections, Intra-Articular; Lidocaine/administration & dosage; Male; Neurons, Afferent/drug effects; Osteoarthritis/complications; Osteoarthritis/drug therapy; Pain/complications; Pain Measurement/drug effects; Pain Measurement/methods; Rats; Rats, Sprague-Dawley; TRPV Cation Channels/physiology; Weight-Bearing/physiology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Osteoarthritis / Pain / Severity of Illness Index / Disease Models, Animal / Neurons, Afferent Limits: Animals Language: En Journal: Pain Year: 2012 Document type: Article Affiliation country: China Country of publication: United States

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