Minor structural modifications to alchemix influence mechanism of action and pharmacological activity.

Abdallah, Qasem M A; Phillips, Roger M; Johansson, Fredrik; Helleday, Thomas; Cosentino, Laura; Abdel-Rahman, Hamdy; Etzad, Jasarat; Wheelhouse, Richard T; Kiakos, Konstantinos; Bingham, John P; Hartley, John A; Patterson, Laurence H; Pors, Klaus

Abdallah, Qasem M A; Phillips, Roger M; Johansson, Fredrik; Helleday, Thomas; Cosentino, Laura; Abdel-Rahman, Hamdy; Etzad, Jasarat; Wheelhouse, Richard T; Kiakos, Konstantinos; Bingham, John P; Hartley, John A; Patterson, Laurence H; Pors, Klaus.

Affiliation

Abdallah QM; Institute of Cancer Therapeutics, University of Bradford, West Yorkshire, UK.

Biochem Pharmacol ; 83(11): 1514-22, 2012 Jun 01.

Article in En | MEDLINE | ID: mdl-22387433

Subject(s)

Anthraquinones/chemistry; Anthraquinones/pharmacology; Antineoplastic Agents/chemistry; Antineoplastic Agents/pharmacology; Animals; CHO Cells; Cell Cycle; Cell Death/drug effects; Cricetinae; DNA Adducts; Gene Expression Regulation, Enzymologic/drug effects; Gene Expression Regulation, Neoplastic/drug effects; HCT116 Cells; Histones/genetics; Histones/metabolism; Humans; Molecular Structure; Structure-Activity Relationship

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Anthraquinones / Antineoplastic Agents Limits: Animals / Humans Language: En Journal: Biochem Pharmacol Year: 2012 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google