Ascorbic acid prevents loss of Dlk1-Dio3 imprinting and facilitates generation of all-iPS cell mice from terminally differentiated B cells.

Stadtfeld, Matthias; Apostolou, Effie; Ferrari, Francesco; Choi, Jiho; Walsh, Ryan M; Chen, Taiping; Ooi, Steen S K; Kim, Sang Yong; Bestor, Timothy H; Shioda, Toshi; Park, Peter J; Hochedlinger, Konrad

Stadtfeld, Matthias; Apostolou, Effie; Ferrari, Francesco; Choi, Jiho; Walsh, Ryan M; Chen, Taiping; Ooi, Steen S K; Kim, Sang Yong; Bestor, Timothy H; Shioda, Toshi; Park, Peter J; Hochedlinger, Konrad.

Affiliation

Stadtfeld M; Massachusetts General Hospital Center for Regenerative Medicine, Harvard Stem Cell Institute, Boston, Massachusetts, USA.

Nat Genet ; 44(4): 398-405, S1-2, 2012 Mar 04.

Article in En | MEDLINE | ID: mdl-22387999

Subject(s)

Ascorbic Acid/pharmacology; B-Lymphocytes/cytology; B-Lymphocytes/metabolism; Genomic Imprinting; Induced Pluripotent Stem Cells; Intercellular Signaling Peptides and Proteins/genetics; Animals; Calcium-Binding Proteins; Cell Differentiation/genetics; Cellular Reprogramming/drug effects; Chromatin; DNA (Cytosine-5-)-Methyltransferases/metabolism; DNA Methylation/drug effects; DNA Methyltransferase 3A; Mice; Octamer Transcription Factor-3/genetics; Promoter Regions, Genetic; Proteins/genetics; Proteins/metabolism; RNA, Long Noncoding

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ascorbic Acid / B-Lymphocytes / Genomic Imprinting / Intercellular Signaling Peptides and Proteins / Induced Pluripotent Stem Cells Limits: Animals Language: En Journal: Nat Genet Journal subject: GENETICA MEDICA Year: 2012 Document type: Article Affiliation country: United States Country of publication: United States

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