Epigenetic regulation of tumor necrosis factor &#945; (TNF&#945;) release in human macrophages by HIV-1 single-stranded RNA (ssRNA) is dependent on TLR8 signaling.

Han, Xinbing; Li, Xin; Yue, Simon C; Anandaiah, Asha; Hashem, Falah; Reinach, Peter S; Koziel, Henry; Tachado, Souvenir D

Epigenetic regulation of tumor necrosis factor α (TNFα) release in human macrophages by HIV-1 single-stranded RNA (ssRNA) is dependent on TLR8 signaling.

Han, Xinbing; Li, Xin; Yue, Simon C; Anandaiah, Asha; Hashem, Falah; Reinach, Peter S; Koziel, Henry; Tachado, Souvenir D.

Affiliation

Han X; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115, USA.

J Biol Chem ; 287(17): 13778-86, 2012 Apr 20.

Article in En | MEDLINE | ID: mdl-22393042

Subject(s)

Epigenesis, Genetic; HIV Infections/metabolism; HIV Infections/virology; HIV-1/metabolism; Macrophages/cytology; RNA/metabolism; Toll-Like Receptor 7/metabolism; Tumor Necrosis Factor-alpha/metabolism; Chromatin/chemistry; Chromatin Assembly and Disassembly; Chromatin Immunoprecipitation; HIV Infections/genetics; Humans; Macrophages, Alveolar/cytology; Oligonucleotides/chemistry; RNA, Viral/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: RNA / HIV Infections / HIV-1 / Tumor Necrosis Factor-alpha / Epigenesis, Genetic / Toll-Like Receptor 7 / Macrophages Type of study: Prognostic_studies Limits: Humans Language: En Journal: J Biol Chem Year: 2012 Document type: Article Affiliation country: United States Country of publication: United States

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