[Structure correction and synthesis of subspinosin].
Yao Xue Xue Bao
; 25(3): 173-7, 1990.
Article
in Zh
| MEDLINE
| ID: mdl-2239332
ABSTRACT
"Subspinosin" isolated from the root of Damnacanthus subspinosus Hand-Mazz (Rubiaceae) and deduced as 3-ethoxymethyl-2-hydroxy-1-methoxyan-thraquinone 1 by Li et al in 1981, should be corrected as 2-ethoxymethyl-3-hydroxy-1-methoxyanthraquinone 5 by comparison with the synthetic compound. Since 5 is already known as damnacanthol-omega-ethyl ether, the name "Subspinosin" for 1 (not yet a natural isolate) should be abandoned in order to acknowledge this priority, and, what is more, to avoid confusion. The anthraquinones 1 and 5 were synthesized by condensation of phthalic anhydride with 3-methylcatechol or 2-methylresorcinol in fused AlCl3/NaCl (51), followed sequentially by selective acetylation, methylation, bromination and condensation with sodium ethoxide.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Anthraquinones
/
Antineoplastic Agents, Phytogenic
Language:
Zh
Journal:
Yao Xue Xue Bao
Year:
1990
Document type:
Article