Trypanosoma brucei solanesyl-diphosphate synthase localizes to the mitochondrion.
Mol Biochem Parasitol
; 183(2): 189-92, 2012 Jun.
Article
in En
| MEDLINE
| ID: mdl-22406034
ABSTRACT
Polyprenyl-diphosphate synthase is a key enzyme in the biosynthesis of ubiquinone, a molecule considered essential for a typical eukaryotic cell. Its orthologue in the American stercorarian flagellate Trypanosoma cruzi, solanesyl diphosphate synthase, has been previously localized into the glycosomes. We wondered whether this unique cellular localization is shared by other trypanosome species. Using digitonin permeabilization, immunofluorescence and in situ tagging techniques, we show that in Trypanosoma brucei, the African salivarian flagellate, the enzyme localizes to the mitochondrion.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Trypanosoma brucei brucei
/
Alkyl and Aryl Transferases
/
Mitochondria
Limits:
Humans
Language:
En
Journal:
Mol Biochem Parasitol
Year:
2012
Document type:
Article
Affiliation country:
United kingdom