Hedgehog-mediated regulation of PPARÎ³ controls metabolic patterns in neural precursors and shh-driven medulloblastoma.

Bhatia, Bobby; Potts, Chad R; Guldal, Cemile; Choi, SunPhil; Korshunov, Andrey; Pfister, Stefan; Kenney, Anna M; Nahlé, Zaher A

Bhatia, Bobby; Potts, Chad R; Guldal, Cemile; Choi, SunPhil; Korshunov, Andrey; Pfister, Stefan; Kenney, Anna M; Nahlé, Zaher A.

Affiliation

Bhatia B; Department of Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.

Acta Neuropathol ; 123(4): 587-600, 2012 Apr.

Article in En | MEDLINE | ID: mdl-22407012

Subject(s)

Cerebellar Neoplasms/metabolism; Medulloblastoma/metabolism; Neural Stem Cells/metabolism; PPAR gamma/metabolism; Anilides/pharmacology; Animals; Animals, Newborn; Azo Compounds; Basic Helix-Loop-Helix Transcription Factors/genetics; Carrier Proteins/metabolism; Cell Proliferation; Cells, Cultured; Cerebellar Neoplasms/diagnostic imaging; Cerebellar Neoplasms/pathology; Cerebellum/cytology; DNA-Binding Proteins/metabolism; E2F1 Transcription Factor/genetics; Enzyme Inhibitors/pharmacology; Gene Expression Regulation, Neoplastic/genetics; Hexokinase/metabolism; Humans; Ki-67 Antigen/metabolism; Medulloblastoma/diagnostic imaging; Medulloblastoma/pathology; Membrane Proteins/metabolism; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neuropeptides/genetics; Positron-Emission Tomography; Thyroid Hormones/metabolism; Time Factors; Transcription Factors/metabolism; Transduction, Genetic/methods; Thyroid Hormone-Binding Proteins

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cerebellar Neoplasms / PPAR gamma / Neural Stem Cells / Medulloblastoma Language: En Journal: Acta Neuropathol Year: 2012 Document type: Article Affiliation country: United States Country of publication: Germany

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