Cyclooxygenase-2 inhibition restores ultraviolet B-induced downregulation of ATP2A2/SERCA2 in keratinocytes: possible therapeutic approach of cyclooxygenase-2 inhibition for treatment of Darier disease.

Kamijo, M; Nishiyama, C; Takagi, A; Nakano, N; Hara, M; Ikeda, S; Okumura, K; Ogawa, H

Kamijo, M; Nishiyama, C; Takagi, A; Nakano, N; Hara, M; Ikeda, S; Okumura, K; Ogawa, H.

Affiliation

Kamijo M; Department of Dermatology, Juntendo University School of Medicine, Bunkyo-ku, Tokyo, Japan.

Br J Dermatol ; 166(5): 1017-22, 2012 May.

Article in En | MEDLINE | ID: mdl-22413864

Subject(s)

Cyclooxygenase 2 Inhibitors/pharmacology; Cyclooxygenase 2/physiology; Darier Disease/therapy; Keratinocytes/physiology; Sarcoplasmic Reticulum Calcium-Transporting ATPases/genetics; Ultraviolet Rays; Cells, Cultured; Dinoprostone/pharmacology; Down-Regulation/drug effects; Down-Regulation/radiation effects; Gene Knockdown Techniques; Humans; Infant, Newborn; Keratinocytes/drug effects; Keratinocytes/metabolism; RNA, Small Interfering/pharmacology; Sarcoplasmic Reticulum Calcium-Transporting ATPases/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ultraviolet Rays / Keratinocytes / Cyclooxygenase 2 / Cyclooxygenase 2 Inhibitors / Sarcoplasmic Reticulum Calcium-Transporting ATPases / Darier Disease Limits: Humans / Newborn Language: En Journal: Br J Dermatol Year: 2012 Document type: Article Affiliation country: Japan Country of publication: United kingdom

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