Optimal induction of myeloma cell death requires dual blockade of phosphoinositide 3-kinase and mTOR signalling and is determined by translocation subtype.

Stengel, C; Cheung, C W; Quinn, J; Yong, K; Khwaja, A

Stengel, C; Cheung, C W; Quinn, J; Yong, K; Khwaja, A.

Affiliation

Stengel C; Department of Haematology, University College London Cancer Institute, London, UK.

Leukemia ; 26(8): 1761-70, 2012 Aug.

Article in En | MEDLINE | ID: mdl-22415553

Subject(s)

Multiple Myeloma/genetics; Multiple Myeloma/metabolism; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors/pharmacology; Signal Transduction/drug effects; TOR Serine-Threonine Kinases/antagonists & inhibitors; Translocation, Genetic; Cell Death/drug effects; Cell Death/genetics; Cell Line, Tumor; Enzyme Activation/genetics; Humans; Multiple Myeloma/enzymology; Phosphatidylinositol 3-Kinases/metabolism; TOR Serine-Threonine Kinases/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Translocation, Genetic / Signal Transduction / Protein Kinase Inhibitors / TOR Serine-Threonine Kinases / Phosphoinositide-3 Kinase Inhibitors / Multiple Myeloma Limits: Humans Language: En Journal: Leukemia Journal subject: HEMATOLOGIA / NEOPLASIAS Year: 2012 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom

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