FT011, a new anti-fibrotic drug, attenuates fibrosis and chronic heart failure in experimental diabetic cardiomyopathy.

Zhang, Yuan; Edgley, Amanda J; Cox, Alison J; Powell, Andrew K; Wang, Bing; Kompa, Andrew R; Stapleton, David I; Zammit, Steven C; Williams, Spencer J; Krum, Henry; Gilbert, Richard E; Kelly, Darren J

Zhang, Yuan; Edgley, Amanda J; Cox, Alison J; Powell, Andrew K; Wang, Bing; Kompa, Andrew R; Stapleton, David I; Zammit, Steven C; Williams, Spencer J; Krum, Henry; Gilbert, Richard E; Kelly, Darren J.

Affiliation

Zhang Y; Department of Medicine, St Vincent's Hospital, University of Melbourne, Australia.

Eur J Heart Fail ; 14(5): 549-62, 2012 May.

Article in En | MEDLINE | ID: mdl-22417655

Subject(s)

Antifibrinolytic Agents/therapeutic use; Caffeic Acids/therapeutic use; Diabetes Mellitus, Experimental/complications; Diabetic Cardiomyopathies/drug therapy; Heart Failure/drug therapy; Myocardium/pathology; Myocytes, Cardiac/pathology; ortho-Aminobenzoates/therapeutic use; Animals; Cardiac Catheterization; Cardiomegaly/etiology; Cardiomegaly/pathology; Chronic Disease; Collagen/metabolism; Fibrosis/drug therapy; Heart Failure/complications; Heart Failure/metabolism; Immunohistochemistry; Male; Rats; Rats, Inbred Strains; Rats, Sprague-Dawley; Streptozocin

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Caffeic Acids / Myocytes, Cardiac / Diabetes Mellitus, Experimental / Diabetic Cardiomyopathies / Ortho-Aminobenzoates / Heart Failure / Myocardium / Antifibrinolytic Agents Type of study: Etiology_studies Limits: Animals Language: En Journal: Eur J Heart Fail Journal subject: CARDIOLOGIA Year: 2012 Document type: Article Affiliation country: Australia

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