A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response.

Chen, Zhao; Cheng, Katherine; Walton, Zandra; Wang, Yuchuan; Ebi, Hiromichi; Shimamura, Takeshi; Liu, Yan; Tupper, Tanya; Ouyang, Jing; Li, Jie; Gao, Peng; Woo, Michele S; Xu, Chunxiao; Yanagita, Masahiko; Altabef, Abigail; Wang, Shumei; Lee, Charles; Nakada, Yuji; Peña, Christopher G; Sun, Yanping; Franchetti, Yoko; Yao, Catherine; Saur, Amy; Cameron, Michael D; Nishino, Mizuki; Hayes, D Neil; Wilkerson, Matthew D; Roberts, Patrick J; Lee, Carrie B; Bardeesy, Nabeel; Butaney, Mohit; Chirieac, Lucian R; Costa, Daniel B; Jackman, David; Sharpless, Norman E; Castrillon, Diego H; Demetri, George D; Jänne, Pasi A; Pandolfi, Pier Paolo; Cantley, Lewis C; Kung, Andrew L; Engelman, Jeffrey A; Wong, Kwok-Kin

Chen, Zhao; Cheng, Katherine; Walton, Zandra; Wang, Yuchuan; Ebi, Hiromichi; Shimamura, Takeshi; Liu, Yan; Tupper, Tanya; Ouyang, Jing; Li, Jie; Gao, Peng; Woo, Michele S; Xu, Chunxiao; Yanagita, Masahiko; Altabef, Abigail; Wang, Shumei; Lee, Charles; Nakada, Yuji; Peña, Christopher G; Sun, Yanping; Franchetti, Yoko; Yao, Catherine; Saur, Amy; Cameron, Michael D; Nishino, Mizuki; Hayes, D Neil; Wilkerson, Matthew D; Roberts, Patrick J; Lee, Carrie B; Bardeesy, Nabeel; Butaney, Mohit; Chirieac, Lucian R; Costa, Daniel B; Jackman, David; Sharpless, Norman E; Castrillon, Diego H; Demetri, George D; Jänne, Pasi A; Pandolfi, Pier Paolo; Cantley, Lewis C; Kung, Andrew L; Engelman, Jeffrey A; Wong, Kwok-Kin.

Affiliation

Chen Z; Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA.

Nature ; 483(7391): 613-7, 2012 Mar 18.

Article in En | MEDLINE | ID: mdl-22425996

Subject(s)

Benzimidazoles/pharmacology; Clinical Trials, Phase II as Topic; Disease Models, Animal; Lung Neoplasms/drug therapy; Lung Neoplasms/genetics; Pharmacogenetics/methods; Taxoids/therapeutic use; AMP-Activated Protein Kinases; Animals; Antineoplastic Combined Chemotherapy Protocols; Benzimidazoles/therapeutic use; Biomarkers, Tumor/genetics; Biomarkers, Tumor/metabolism; Docetaxel; Drug Evaluation, Preclinical; Fluorodeoxyglucose F18; Genes, p53/genetics; Humans; Lung Neoplasms/enzymology; Lung Neoplasms/metabolism; MAP Kinase Signaling System/drug effects; Mice; Mitogen-Activated Protein Kinase Kinases/antagonists & inhibitors; Mutation/genetics; Positron-Emission Tomography; Protein Serine-Threonine Kinases/deficiency; Protein Serine-Threonine Kinases/genetics; Proto-Oncogene Proteins/genetics; Proto-Oncogene Proteins/metabolism; Proto-Oncogene Proteins p21(ras)/genetics; Proto-Oncogene Proteins p21(ras)/metabolism; Randomized Controlled Trials as Topic; Reproducibility of Results; Tomography, X-Ray Computed; Treatment Outcome; ras Proteins/genetics; ras Proteins/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pharmacogenetics / Benzimidazoles / Clinical Trials, Phase II as Topic / Taxoids / Disease Models, Animal / Lung Neoplasms Type of study: Clinical_trials / Prognostic_studies Limits: Animals / Humans Language: En Journal: Nature Year: 2012 Document type: Article Affiliation country: United States Country of publication: United kingdom

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