Isoniazid resistance without a loss of fitness in Mycobacterium tuberculosis.

Lee, Jong-Hee; Ammerman, Nicole C; Nolan, Scott; Geiman, Deborah E; Lun, Shichun; Guo, Haidan; Bishai, William R

Lee, Jong-Hee; Ammerman, Nicole C; Nolan, Scott; Geiman, Deborah E; Lun, Shichun; Guo, Haidan; Bishai, William R.

Affiliation

Lee JH; Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA.

Nat Commun ; 3: 753, 2012 Mar 20.

Article in En | MEDLINE | ID: mdl-22434196

Subject(s)

Antitubercular Agents/pharmacology; Isoniazid/pharmacology; Mycobacterium tuberculosis/drug effects; Mycobacterium tuberculosis/genetics; Sigma Factor/genetics; Tuberculosis, Multidrug-Resistant/microbiology; Animals; Bacterial Proteins/biosynthesis; Bacterial Proteins/genetics; Bacterial Proteins/metabolism; Catalase/biosynthesis; Catalase/genetics; Drug Resistance, Multiple, Bacterial; Genes, Bacterial; Genes, Regulator; Macrophages/immunology; Macrophages/microbiology; Mice; Mice, Inbred BALB C; Mycobacterium tuberculosis/metabolism; Mycobacterium tuberculosis/pathogenicity; Regulon; Transcription, Genetic; Tuberculosis/drug therapy; Tuberculosis/microbiology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sigma Factor / Tuberculosis, Multidrug-Resistant / Isoniazid / Mycobacterium tuberculosis / Antitubercular Agents Limits: Animals Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2012 Document type: Article Affiliation country: United States Country of publication: United kingdom

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