Research on the stability of a rabbit dry eye model induced by topical application of the preservative benzalkonium chloride.

Li, Chaoyang; Song, Yiyue; Luan, Shaohong; Wan, Pengxia; Li, Naiyang; Tang, Jing; Han, Yu; Xiong, Cuiju; Wang, Zhichong

Li, Chaoyang; Song, Yiyue; Luan, Shaohong; Wan, Pengxia; Li, Naiyang; Tang, Jing; Han, Yu; Xiong, Cuiju; Wang, Zhichong.

Affiliation

Li C; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.

PLoS One ; 7(3): e33688, 2012.

Article in En | MEDLINE | ID: mdl-22438984

Subject(s)

Benzalkonium Compounds/toxicity; Dry Eye Syndromes/chemically induced; Preservatives, Pharmaceutical/toxicity; Animals; Benzalkonium Compounds/administration & dosage; Conjunctiva/pathology; Cornea/drug effects; Cornea/pathology; Disease Models, Animal; Dry Eye Syndromes/pathology; Dry Eye Syndromes/physiopathology; Female; Goblet Cells/drug effects; Goblet Cells/pathology; Humans; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Mucin 5AC/metabolism; Ophthalmic Solutions; Preservatives, Pharmaceutical/administration & dosage; Rabbits; Tears/metabolism; Time Factors

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Preservatives, Pharmaceutical / Benzalkonium Compounds / Dry Eye Syndromes Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2012 Document type: Article Affiliation country: China Country of publication: United States

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