Overcoming non-specific adsorption issues for AZD9164 in human urine samples: consideration of bioanalytical and metabolite identification procedures.

Silvester, Steve; Zang, Frank

Silvester, Steve; Zang, Frank.

Affiliation

Silvester S; Department of Clinical Pharmacology & DMPK, AstraZeneca R&D Charnwood, Bakewell Road, Loughborough LE11 5RH, UK. stephen.silvester@astrazeneca.com

J Chromatogr B Analyt Technol Biomed Life Sci ; 893-894: 134-43, 2012 Apr 15.

Article in En | MEDLINE | ID: mdl-22440890

Subject(s)

Chromatography, Liquid/methods; Piperidines/urine; Quinuclidines/urine; Tandem Mass Spectrometry/methods; Adsorption; Cholic Acids/chemistry; Humans; Piperidines/chemistry; Piperidines/pharmacokinetics; Quinuclidines/chemistry; Quinuclidines/pharmacokinetics; Reproducibility of Results; Surface-Active Agents/chemistry

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Piperidines / Quinuclidines / Chromatography, Liquid / Tandem Mass Spectrometry Type of study: Diagnostic_studies Limits: Humans Language: En Journal: J Chromatogr B Analyt Technol Biomed Life Sci Journal subject: ENGENHARIA BIOMEDICA Year: 2012 Document type: Article Affiliation country: United kingdom Country of publication: Netherlands

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