Effects of nanostructurized silicon on proliferation of stem and cancer cell.
Bull Exp Biol Med
; 151(1): 79-83, 2011 May.
Article
in En
| MEDLINE
| ID: mdl-22442808
ABSTRACT
In vitro experiments showed that stem and cancer cells retained their viability on the surface of porous silicon with 10-100 nm nanostructures, but their proliferation was inhibited. Silicon nanoparticles of 100 nm in size obtained by mechanical grinding of porous silicon films or crystal silicon plates in a concentration below 1 mg/ml in solution did not modify viability and proliferation of mouse fibroblast and human laryngeal cancer cells. Additional ultrasonic exposure of cancer cells in the presence of 1 mg/ml silicon nanoparticles added to nutrient medium led to complete destruction of cells or to the appearance of membrane defects blocking their proliferation and initiating their apoptotic death.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Silicon
/
Stem Cells
/
Apoptosis
Limits:
Animals
/
Humans
Language:
En
Journal:
Bull Exp Biol Med
Year:
2011
Document type:
Article
Affiliation country:
RUSSIA