Genetic toxicology evaluation of essential oil of Alpinia zerumbet and its chemoprotective effects against H(2)O(2)-induced DNA damage in cultured human leukocytes.

Cavalcanti, Bruno C; Ferreira, José R O; Cabral, Igor O; Magalhães, Hemerson I F; de Oliveira, Cecília C; Rodrigues, Felipe A R; Rocha, Danilo D; Barros, Francisco W A; da Silva, Cecília R; Júnior, Hélio V N; Canuto, Kirley M; Silveira, Edilberto R; Pessoa, Cláudia; Moraes, Manoel O

Cavalcanti, Bruno C; Ferreira, José R O; Cabral, Igor O; Magalhães, Hemerson I F; de Oliveira, Cecília C; Rodrigues, Felipe A R; Rocha, Danilo D; Barros, Francisco W A; da Silva, Cecília R; Júnior, Hélio V N; Canuto, Kirley M; Silveira, Edilberto R; Pessoa, Cláudia; Moraes, Manoel O.

Affiliation

Cavalcanti BC; National Laboratory of Experimental Oncology, Department of Physiology and Pharmacology, Federal University of Ceará, P.O. Box 3157, CEP 60430-270 Fortaleza, Ceará, Brazil.

Food Chem Toxicol ; 50(11): 4051-61, 2012 Nov.

Article in En | MEDLINE | ID: mdl-22446814

Subject(s)

Alpinia/chemistry; DNA Damage/drug effects; Leukocytes/drug effects; Oils, Volatile/pharmacology; Protective Agents/pharmacology; Animals; Antioxidants/pharmacology; Apoptosis/drug effects; Chromosome Aberrations; Female; Free Radical Scavengers/pharmacology; Gas Chromatography-Mass Spectrometry; Glutathione/metabolism; Humans; Hydrogen Peroxide/toxicity; Leukocytes/metabolism; Lipid Peroxidation/drug effects; Male; Mice; Micronucleus Tests; Mutagenicity Tests; Oils, Volatile/analysis; Oils, Volatile/chemistry; Reactive Oxygen Species/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA Damage / Oils, Volatile / Protective Agents / Alpinia / Leukocytes Limits: Animals / Female / Humans / Male Language: En Journal: Food Chem Toxicol Year: 2012 Document type: Article Affiliation country: Brazil Country of publication: United kingdom

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