A computationally optimized hemagglutinin virus-like particle vaccine elicits broadly reactive antibodies that protect nonhuman primates from H5N1 infection.

Giles, Brendan M; Crevar, Corey J; Carter, Donald M; Bissel, Stephanie J; Schultz-Cherry, Stacey; Wiley, Clayton A; Ross, Ted M

Giles, Brendan M; Crevar, Corey J; Carter, Donald M; Bissel, Stephanie J; Schultz-Cherry, Stacey; Wiley, Clayton A; Ross, Ted M.

Affiliation

Giles BM; Center for Vaccine Research, University of Pittsburgh, Pennsylvania 15261, USA.

J Infect Dis ; 205(10): 1562-70, 2012 May 15.

Article in En | MEDLINE | ID: mdl-22448011

Subject(s)

Antibodies, Viral/blood; Hemagglutinins, Viral/immunology; Influenza A Virus, H5N1 Subtype/immunology; Influenza Vaccines/immunology; Influenza, Human/prevention & control; Orthomyxoviridae Infections/prevention & control; Amino Acid Sequence; Animals; Antigens, Viral/immunology; Cell Line, Transformed; Computer-Aided Design; Consensus Sequence; Disease Models, Animal; Hemagglutinins, Viral/chemistry; Humans; Influenza, Human/immunology; Influenza, Human/virology; Likelihood Functions; Lung/virology; Macaca fascicularis; Male; Orthomyxoviridae Infections/immunology; Orthomyxoviridae Infections/virology; Phylogeny; Vaccination; Vaccines, Virus-Like Particle/immunology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Influenza Vaccines / Orthomyxoviridae Infections / Influenza, Human / Influenza A Virus, H5N1 Subtype / Hemagglutinins, Viral / Antibodies, Viral Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: J Infect Dis Year: 2012 Document type: Article Affiliation country: United States Country of publication: United States

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