Searching for new chemotherapies for tropical diseases: ruthenium-clotrimazole complexes display high in vitro activity against Leishmania major and Trypanosoma cruzi and low toxicity toward normal mammalian cells.

Martínez, Alberto; Carreon, Teresia; Iniguez, Eva; Anzellotti, Atilio; Sánchez, Antonio; Tyan, Marina; Sattler, Aaron; Herrera, Linda; Maldonado, Rosa A; Sánchez-Delgado, Roberto A

Martínez, Alberto; Carreon, Teresia; Iniguez, Eva; Anzellotti, Atilio; Sánchez, Antonio; Tyan, Marina; Sattler, Aaron; Herrera, Linda; Maldonado, Rosa A; Sánchez-Delgado, Roberto A.

Affiliation

Martínez A; Chemistry Department, Brooklyn College and The Graduate Center, The City University of New York, Brooklyn, New York 11210, USA.

J Med Chem ; 55(8): 3867-77, 2012 Apr 26.

Article in En | MEDLINE | ID: mdl-22448965

Subject(s)

Antiprotozoal Agents/therapeutic use; Clotrimazole/therapeutic use; Leishmania major/drug effects; Organometallic Compounds/therapeutic use; Ruthenium/therapeutic use; Trypanosoma cruzi/drug effects; Animals; Antiprotozoal Agents/chemical synthesis; Antiprotozoal Agents/chemistry; Cell Line; Clotrimazole/chemistry; Crystallography, X-Ray; Humans; Mice; Organometallic Compounds/chemical synthesis; Organometallic Compounds/chemistry; Ruthenium/chemistry

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Organometallic Compounds / Ruthenium / Trypanosoma cruzi / Clotrimazole / Leishmania major / Antiprotozoal Agents Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2012 Document type: Article Affiliation country: United States

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