MMP-2 and MMP-9 in normal mucosa are independently associated with outcome of colorectal cancer patients.
Br J Cancer
; 106(9): 1495-8, 2012 Apr 24.
Article
in En
| MEDLINE
| ID: mdl-22472880
ABSTRACT
BACKGROUND:
Upregulation of the matrix metalloproteinases MMP-2 and MMP-9 in various cancers has been associated with worse survival of the patients.METHODS:
We assessed MMP-2 and MMP-9 levels in normal colorectal mucosa from colorectal cancer patients in relation to the course of the disease.RESULTS:
A high protein expression of MMP-2 as well as MMP-9 in normal mucosa was found to be correlated with worse 5-year survival. The combination of both parameters was an even stronger prognostic factor. These protein levels were found not to be related to the corresponding single nucleotide polymorphisms of MMP-2 (-1306C>T) and MMP-9 (-1562C>T). Multivariate analyses indicated that the MMP-2 and MMP-9 levels in normal mucosa are prognostic for survival, independent of TNM classification.CONCLUSION:
MMP-2 and MMP-9 levels in normal mucosa are indicative of the course of disease in colorectal cancer patients.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Colorectal Neoplasms
/
Matrix Metalloproteinase 2
/
Matrix Metalloproteinase 9
/
Mucous Membrane
Type of study:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Aged
/
Female
/
Humans
/
Male
Language:
En
Journal:
Br J Cancer
Year:
2012
Document type:
Article
Affiliation country:
Netherlands