Identification of selective inhibitors of the potassium channel Kv1.1-1.2((3)) by high-throughput virtual screening and automated patch clamp.

Wacker, Sören J; Jurkowski, Wiktor; Simmons, Katie J; Fishwick, Colin W G; Johnson, A Peter; Madge, David; Lindahl, Erik; Rolland, Jean-Francois; de Groot, Bert L

Wacker, Sören J; Jurkowski, Wiktor; Simmons, Katie J; Fishwick, Colin W G; Johnson, A Peter; Madge, David; Lindahl, Erik; Rolland, Jean-Francois; de Groot, Bert L.

Affiliation

Wacker SJ; Max Planck Institute for Biophysical Chemistry, Computational Biomolecular Dynamics Group, Am Fassberg 11, 37077 Göttingen, Germany.

ChemMedChem ; 7(10): 1775-83, 2012 Oct.

Article in En | MEDLINE | ID: mdl-22473914

Subject(s)

Kv1.1 Potassium Channel/antagonists & inhibitors; Kv1.2 Potassium Channel/antagonists & inhibitors; Potassium Channel Blockers/chemistry; Animals; Automation; Binding Sites; CHO Cells; Cricetinae; Cricetulus; High-Throughput Screening Assays; Kv1.1 Potassium Channel/metabolism; Kv1.2 Potassium Channel/metabolism; Membrane Potentials/drug effects; Molecular Docking Simulation; Patch-Clamp Techniques; Potassium Channel Blockers/pharmacology; Protein Structure, Tertiary; ROC Curve; Small Molecule Libraries/chemistry; Small Molecule Libraries/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Potassium Channel Blockers / Kv1.1 Potassium Channel / Kv1.2 Potassium Channel Type of study: Diagnostic_studies / Prognostic_studies / Screening_studies Limits: Animals Language: En Journal: ChemMedChem Journal subject: FARMACOLOGIA / QUIMICA Year: 2012 Document type: Article Affiliation country: Germany

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