Inhibition of HSP27 alone or in combination with pAKT inhibition as therapeutic approaches to target SPARC-induced glioma cell survival.

Schultz, Chad R; Golembieski, William A; King, Daniel A; Brown, Stephen L; Brodie, Chaya; Rempel, Sandra A

Schultz, Chad R; Golembieski, William A; King, Daniel A; Brown, Stephen L; Brodie, Chaya; Rempel, Sandra A.

Affiliation

Schultz CR; The Barbara Jane Levy Laboratory of Molecular Neuro-Oncology, Henry Ford Hospital, Detroit, MI 48202, USA.

Mol Cancer ; 11: 20, 2012 Apr 05.

Article in En | MEDLINE | ID: mdl-22480225

Subject(s)

HSP27 Heat-Shock Proteins/metabolism; Osteonectin/metabolism; Proto-Oncogene Proteins c-akt/metabolism; Apoptosis/drug effects; Apoptosis/genetics; Blotting, Western; Cell Line, Tumor; Dacarbazine/analogs & derivatives; Dacarbazine/pharmacology; Glioma; HSP27 Heat-Shock Proteins/genetics; Humans; Osteonectin/genetics; Proto-Oncogene Proteins c-akt/genetics; RNA, Small Interfering; Temozolomide

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Osteonectin / Proto-Oncogene Proteins c-akt / HSP27 Heat-Shock Proteins Limits: Humans Language: En Journal: Mol Cancer Journal subject: NEOPLASIAS Year: 2012 Document type: Article Affiliation country: United States Country of publication: United kingdom

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