[Short-course treatment of vulvovaginal candidiasis: comparative study of fluconazole and intra-vaginal fenticonazole]. / Il trattamento "short course" della candidosi vulvovaginale acuta: studio comparativo tra il fluconazolo ed il fenticonazolo intravaginale.
Minerva Ginecol
; 64(2): 89-94, 2012 Apr.
Article
in It
| MEDLINE
| ID: mdl-22481619
ABSTRACT
AIM:
The aim of this paper was to compare the efficacy of fluconazole 150 mg and intra-vaginal fenticonazole 600mg in short-course treatment of the acute episode of vulvovaginal candidiasis (VVC).METHODS:
In a prospective study, 80 patients with clinical and mycological (SavvyCheck™ test) confirmed VVC were enrolled and divided randomly in two groups. Forty patients received oral fluconazole (150 mg), whereas 40 patients received intra-vaginal tablet fenticonazole (600 mg). Two sequential doses of azole agents were given 3 days apart (short-course treatment). Second and third visits were done for all patients seven and 30±5 days after treatment.RESULTS:
At the second visit, 31 patients (77.5%) were cured clinically (Sobel score <4) in fluconazole group and 32 patients (80%) in fenticonazole group (P=0.876). The vulvovaginal pruritus was reduced in lower time in fenticonazole patients than in fluconazole group (mean 2.3 days versus 4.5 days, P=0.047). At the third visit, three patients in fluconazole group and two patients in fenticonazole group had clinical sign of VVC.CONCLUSION:
Fluconazole and intravaginal fenticonazole are both effective to cure symptoms of VVC but fenticonazole appears to reduce the pruritus in less time.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Candidiasis, Vulvovaginal
/
Fluconazole
/
Imidazoles
/
Antifungal Agents
Type of study:
Clinical_trials
/
Observational_studies
Limits:
Adult
/
Female
/
Humans
Language:
It
Journal:
Minerva Ginecol
Year:
2012
Document type:
Article
Affiliation country:
Italy