Molecular dynamics, crystallography and mutagenesis studies on the substrate gating mechanism of prolyl oligopeptidase.

Kaszuba, Karol; Róg, Tomasz; Danne, Reinis; Canning, Peter; Fülöp, Vilmos; Juhász, Tünde; Szeltner, Zoltán; St Pierre, J-F; García-Horsman, Arturo; Männistö, Pekka T; Karttunen, Mikko; Hokkanen, Jyrki; Bunker, Alex

Kaszuba, Karol; Róg, Tomasz; Danne, Reinis; Canning, Peter; Fülöp, Vilmos; Juhász, Tünde; Szeltner, Zoltán; St Pierre, J-F; García-Horsman, Arturo; Männistö, Pekka T; Karttunen, Mikko; Hokkanen, Jyrki; Bunker, Alex.

Affiliation

Kaszuba K; Department of Physics, Tampere University of Technology, Tampere, Finland.

Biochimie ; 94(6): 1398-411, 2012 Jun.

Article in En | MEDLINE | ID: mdl-22484394

Subject(s)

Serine Endopeptidases/chemistry; Serine Endopeptidases/metabolism; Amino Acid Sequence; Animals; Catalytic Domain; Computer Simulation; Crystallography, X-Ray; Hydrogen Bonding; Kinetics; Models, Molecular; Molecular Dynamics Simulation; Prolyl Oligopeptidases; Protein Conformation; Protein Structure, Tertiary; Serine Endopeptidases/drug effects; Serine Endopeptidases/genetics; Serine Proteinase Inhibitors/pharmacology; Substrate Specificity; Swine; Trypsin/pharmacology

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Serine Endopeptidases Limits: Animals Language: En Journal: Biochimie Year: 2012 Document type: Article Affiliation country: Finland Country of publication: France

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google