Increased plasma S-adenosyl-homocysteine levels induce the proliferation and migration of VSMCs through an oxidative stress-ERK1/2 pathway in apoE(-/-) mice.

Luo, Xiaoqin; Xiao, Yunjun; Song, Fenglin; Yang, Yan; Xia, Min; Ling, Wenhua

Luo, Xiaoqin; Xiao, Yunjun; Song, Fenglin; Yang, Yan; Xia, Min; Ling, Wenhua.

Affiliation

Luo X; Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-Sen University, 74 Zhongshan Road II, Guangzhou 510080, PR China.

Cardiovasc Res ; 95(2): 241-50, 2012 Jul 15.

Article in En | MEDLINE | ID: mdl-22492673

Subject(s)

Apolipoproteins E/metabolism; MAP Kinase Signaling System/drug effects; Muscle, Smooth, Vascular/metabolism; Myocytes, Smooth Muscle/metabolism; Oxidative Stress; S-Adenosylhomocysteine/blood; Animals; Apolipoproteins E/deficiency; Atherosclerosis/etiology; Atherosclerosis/metabolism; Cell Movement/drug effects; Cell Proliferation/drug effects; Dietary Supplements/adverse effects; Methionine/administration & dosage; Methionine/pharmacology; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular/cytology; Myocytes, Smooth Muscle/cytology; Oxidative Stress/drug effects; S-Adenosylhomocysteine/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Apolipoproteins E / S-Adenosylhomocysteine / Oxidative Stress / MAP Kinase Signaling System / Myocytes, Smooth Muscle / Muscle, Smooth, Vascular Type of study: Etiology_studies Limits: Animals Language: En Journal: Cardiovasc Res Year: 2012 Document type: Article Country of publication: United kingdom

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