TASK-3 channel deletion in mice recapitulates low-renin essential hypertension.

Guagliardo, Nick A; Yao, Junlan; Hu, Changlong; Schertz, Elaine M; Tyson, David A; Carey, Robert M; Bayliss, Douglas A; Barrett, Paula Q

Guagliardo, Nick A; Yao, Junlan; Hu, Changlong; Schertz, Elaine M; Tyson, David A; Carey, Robert M; Bayliss, Douglas A; Barrett, Paula Q.

Affiliation

Guagliardo NA; Department of Pharmacology, University of Virginia, School of Medicine, Charlottesville, VA 22908, USA.

Hypertension ; 59(5): 999-1005, 2012 May.

Article in En | MEDLINE | ID: mdl-22493079

Subject(s)

Hyperaldosteronism/genetics; Hypertension/genetics; Hypertension/physiopathology; Potassium Channels/genetics; Renin-Angiotensin System/genetics; Aldosterone/metabolism; Angiotensin II/pharmacology; Animals; Disease Models, Animal; Gene Expression Regulation; Humans; Hyperaldosteronism/physiopathology; Mice; Mice, Inbred C57BL; Mice, Knockout; Potassium Channels/metabolism; Random Allocation; Real-Time Polymerase Chain Reaction; Renin-Angiotensin System/physiology; Sensitivity and Specificity; Sequence Deletion; Sodium/metabolism; Sodium/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Renin-Angiotensin System / Potassium Channels / Hyperaldosteronism / Hypertension Type of study: Clinical_trials / Diagnostic_studies / Prognostic_studies Limits: Animals / Humans Language: En Journal: Hypertension Year: 2012 Document type: Article Affiliation country: United States Country of publication: United States

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