In vivo role of focal adhesion kinase in regulating pancreatic ß-cell mass and function through insulin signaling, actin dynamics, and granule trafficking.

Cai, Erica P; Casimir, Marina; Schroer, Stephanie A; Luk, Cynthia T; Shi, Sally Yu; Choi, Diana; Dai, Xiao Qing; Hajmrle, Catherine; Spigelman, Aliya F; Zhu, Dan; Gaisano, Herbert Y; MacDonald, Patrick E; Woo, Minna

Cai, Erica P; Casimir, Marina; Schroer, Stephanie A; Luk, Cynthia T; Shi, Sally Yu; Choi, Diana; Dai, Xiao Qing; Hajmrle, Catherine; Spigelman, Aliya F; Zhu, Dan; Gaisano, Herbert Y; MacDonald, Patrick E; Woo, Minna.

Affiliation

Cai EP; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.

Diabetes ; 61(7): 1708-18, 2012 Jul.

Article in En | MEDLINE | ID: mdl-22498697

Subject(s)

Actin Cytoskeleton/metabolism; Focal Adhesion Kinase 1/metabolism; Insulin Resistance; Insulin-Secreting Cells/metabolism; Insulin/metabolism; Animals; Calcium/metabolism; Caspase 3/biosynthesis; Cell Survival; Exocytosis; Female; Focal Adhesion Kinase 1/genetics; Glucose Intolerance/genetics; Insulin/genetics; Insulin Secretion; Insulin-Secreting Cells/cytology; MAP Kinase Signaling System; Male; Mice; Paxillin/metabolism; Proto-Oncogene Proteins c-akt/metabolism; Rats; Talin/metabolism; Transport Vesicles/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Actin Cytoskeleton / Insulin Resistance / Insulin-Secreting Cells / Focal Adhesion Kinase 1 / Insulin Type of study: Prognostic_studies Limits: Animals Language: En Journal: Diabetes Year: 2012 Document type: Article Affiliation country: Canada Country of publication: United States

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