Role of human CYP3A4 in the biotransformation of sorafenib to its major oxidized metabolites.

Ghassabian, Sussan; Rawling, Tristan; Zhou, Fanfan; Doddareddy, Munikumar R; Tattam, Bruce N; Hibbs, David E; Edwards, Robert J; Cui, Pei H; Murray, Michael

Ghassabian, Sussan; Rawling, Tristan; Zhou, Fanfan; Doddareddy, Munikumar R; Tattam, Bruce N; Hibbs, David E; Edwards, Robert J; Cui, Pei H; Murray, Michael.

Affiliation

Ghassabian S; Pharmacogenomics and Drug Development Group, University of Sydney, Sydney, NSW 2006, Australia.

Biochem Pharmacol ; 84(2): 215-23, 2012 Jul 15.

Article in En | MEDLINE | ID: mdl-22513143

Subject(s)

Benzenesulfonates/metabolism; Cytochrome P-450 CYP3A/metabolism; Pyridines/metabolism; Benzenesulfonates/pharmacokinetics; Catalytic Domain; Cytochrome P-450 CYP3A/chemistry; Cytochrome P-450 CYP3A/genetics; Humans; Inactivation, Metabolic; Microsomes, Liver/drug effects; Microsomes, Liver/metabolism; Models, Molecular; Niacinamide/analogs & derivatives; Oxidation-Reduction; Phenylurea Compounds; Protein Conformation; Pyridines/pharmacokinetics; Sorafenib

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Benzenesulfonates / Cytochrome P-450 CYP3A Type of study: Prognostic_studies Limits: Humans Language: En Journal: Biochem Pharmacol Year: 2012 Document type: Article Affiliation country: Australia

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