Stereoselective metabolism of tetrahydropalmatine enantiomers in rat liver microsomes.

Zhao, Ming; Li, Li-Ping; Sun, Dong-Li; Sun, Si-Yuan; Huang, Shan-Ding; Zeng, Su; Jiang, Hui-Di

Zhao, Ming; Li, Li-Ping; Sun, Dong-Li; Sun, Si-Yuan; Huang, Shan-Ding; Zeng, Su; Jiang, Hui-Di.

Affiliation

Zhao M; Department of Pharmaceutical Analysis and Drug Metabolism, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, People's Republic of China.

Chirality ; 24(5): 368-73, 2012 May.

Article in En | MEDLINE | ID: mdl-22517372

Subject(s)

Berberine Alkaloids/chemistry; Berberine Alkaloids/metabolism; Microsomes, Liver/metabolism; Animals; Berberine Alkaloids/pharmacokinetics; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP3A/metabolism; Cytochrome P-450 CYP3A Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System/metabolism; Cytochromes/antagonists & inhibitors; Cytochromes/metabolism; Dexamethasone/pharmacology; Dogs; Fluvoxamine/pharmacology; Haplorhini; Ketoconazole/pharmacology; Male; Membrane Proteins/antagonists & inhibitors; Membrane Proteins/metabolism; Metabolic Clearance Rate; Mice; Mice, Inbred ICR; Microsomes, Liver/drug effects; Rats; Rats, Sprague-Dawley; Stereoisomerism; Substrate Specificity; beta-Naphthoflavone/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Berberine Alkaloids / Microsomes, Liver Limits: Animals Language: En Journal: Chirality Journal subject: BIOLOGIA MOLECULAR / QUIMICA Year: 2012 Document type: Article

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