Dose-finding designs in pediatric phase I clinical trials: comparison by simulations in a realistic timeline framework.

Doussau, A; Asselain, B; Le Deley, M C; Geoerger, B; Doz, F; Vassal, G; Paoletti, X

Doussau, A; Asselain, B; Le Deley, M C; Geoerger, B; Doz, F; Vassal, G; Paoletti, X.

Affiliation

Doussau A; Institut Curie, Biostatistics department, Paris, France. adelaide.doussau@isped.u-bordeaux2.fr

Contemp Clin Trials ; 33(4): 657-65, 2012 Jul.

Article in En | MEDLINE | ID: mdl-22521954

Subject(s)

Algorithms; Clinical Trials, Phase I as Topic/methods; Models, Statistical; Research Design; Antineoplastic Agents/administration & dosage; Antineoplastic Agents/therapeutic use; Child; Computer Simulation; Dose-Response Relationship, Drug; Humans; Maximum Tolerated Dose; Neoplasms/drug therapy; No-Observed-Adverse-Effect Level; Patient Selection; Time Factors

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Research Design / Algorithms / Models, Statistical / Clinical Trials, Phase I as Topic Type of study: Diagnostic_studies / Evaluation_studies / Prognostic_studies Limits: Child / Humans Language: En Journal: Contemp Clin Trials Journal subject: MEDICINA / TERAPEUTICA Year: 2012 Document type: Article Affiliation country: France

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