Whole transcriptome characterization of aberrant splicing events induced by lentiviral vector integrations.

Cesana, Daniela; Sgualdino, Jacopo; Rudilosso, Laura; Merella, Stefania; Naldini, Luigi; Montini, Eugenio

Cesana, Daniela; Sgualdino, Jacopo; Rudilosso, Laura; Merella, Stefania; Naldini, Luigi; Montini, Eugenio.

Affiliation

Cesana D; San Raffaele Telethon Institute for Gene Therapy and Division of Regenerative Medicine, Stem Cells and Gene Therapy, Milan, Italy.

J Clin Invest ; 122(5): 1667-76, 2012 May.

Article in En | MEDLINE | ID: mdl-22523064

Subject(s)

Alternative Splicing; Lentivirus Infections/genetics; Lentivirus/physiology; Protein Isoforms/genetics; Transcriptome; Virus Integration; Base Sequence; Cells, Cultured; Gene Expression Profiling; Genes, Essential; Hematopoietic Stem Cells/virology; Humans; Lentivirus/genetics; Mutagenesis, Insertional; Mutant Chimeric Proteins/genetics; Mutant Chimeric Proteins/metabolism; Polymerase Chain Reaction/methods; Primary Cell Culture; Protein Isoforms/metabolism; RNA, Messenger/genetics; RNA, Messenger/metabolism; Real-Time Polymerase Chain Reaction; Terminal Repeat Sequences

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Lentivirus Infections / Virus Integration / Alternative Splicing / Lentivirus / Protein Isoforms / Transcriptome Limits: Humans Language: En Journal: J Clin Invest Year: 2012 Document type: Article Affiliation country: Italy Country of publication: United States

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