Phytanic acid disturbs mitochondrial homeostasis in heart of young rats: a possible pathomechanism of cardiomyopathy in Refsum disease.

Grings, Mateus; Tonin, Anelise Miotti; Knebel, Lisiane Aurélio; Zanatta, Angela; Moura, Alana Pimentel; Filho, Carlos Severo Dutra; Wajner, Moacir; Leipnitz, Guilhian

Grings, Mateus; Tonin, Anelise Miotti; Knebel, Lisiane Aurélio; Zanatta, Angela; Moura, Alana Pimentel; Filho, Carlos Severo Dutra; Wajner, Moacir; Leipnitz, Guilhian.

Affiliation

Grings M; Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos N° 2600-Anexo, Porto Alegre, RS, CEP 90035-003, Brazil.

Mol Cell Biochem ; 366(1-2): 335-43, 2012 Jul.

Article in En | MEDLINE | ID: mdl-22527938

Subject(s)

Cardiomyopathies/metabolism; Homeostasis/drug effects; Mitochondria, Heart/drug effects; Myocardium/pathology; Phytanic Acid/pharmacology; Refsum Disease/metabolism; Animals; Antioxidants/pharmacology; Chromans/pharmacology; Electron Transport Chain Complex Proteins/metabolism; Glutathione/pharmacology; In Vitro Techniques; Male; Membrane Potential, Mitochondrial/drug effects; Mitochondria, Heart/metabolism; Myocardium/metabolism; NADP/metabolism; NG-Nitroarginine Methyl Ester/pharmacology; Nitric Oxide Synthase/antagonists & inhibitors; Oxidation-Reduction; Oxidative Stress; Protein Carbonylation; Rats; Rats, Wistar; Thiobarbituric Acid Reactive Substances/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phytanic Acid / Refsum Disease / Homeostasis / Mitochondria, Heart / Cardiomyopathies / Myocardium Limits: Animals Language: En Journal: Mol Cell Biochem Year: 2012 Document type: Article Affiliation country: Brazil Country of publication: Netherlands

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