A circular dichroism study uncovers a two-step interaction of antitumor azolato-bridged dinuclear platinum(II) complexes with calf thymus DNA.

Uemura, Masako; Yoshikawa, Yuko; Chikuma, Masahiko; Komeda, Seiji

Uemura, Masako; Yoshikawa, Yuko; Chikuma, Masahiko; Komeda, Seiji.

Affiliation

Uemura M; Faculty of Pharmaceutical Sciences, Suzuka University of Medical Science, Suzuka, Mie 513-8670, Japan.

Metallomics ; 4(7): 641-4, 2012 Jul.

Article in En | MEDLINE | ID: mdl-22538714

Subject(s)

Antineoplastic Agents/metabolism; Circular Dichroism/methods; DNA/metabolism; Platinum/metabolism; Animals; Antineoplastic Agents/chemistry; Cattle; Cisplatin/chemistry; Cisplatin/metabolism; DNA/chemistry; Dimerization; Platinum/chemistry

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Platinum / DNA / Circular Dichroism / Antineoplastic Agents Limits: Animals Language: En Journal: Metallomics Journal subject: BIOQUIMICA Year: 2012 Document type: Article Affiliation country: Japan

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