Validation of a liquid chromatography/tandem mass spectrometry method for the simultaneous quantification of Sotrastaurin and its metabolite N-desmethyl-sotrastaurin in human blood.

Jakab, Annamaria; Winter, Serge; Guy, Bertrand; Raccuglia, Marc; Picard, Frank; Kovarik, John M; Chudasama, Jayraj; Guttikar, Swati; Singhal, Puran; Kretz, Olivier

Jakab, Annamaria; Winter, Serge; Guy, Bertrand; Raccuglia, Marc; Picard, Frank; Kovarik, John M; Chudasama, Jayraj; Guttikar, Swati; Singhal, Puran; Kretz, Olivier.

Affiliation

Jakab A; Novartis Institutes for BioMedical Research, DMPK, Fabrikstrasse 14, CH-4056 Basel, Switzerland. annamaria.jakab@novartis.com

J Chromatogr B Analyt Technol Biomed Life Sci ; 897: 10-6, 2012 May 15.

Article in En | MEDLINE | ID: mdl-22541169

Subject(s)

Chromatography, High Pressure Liquid/methods; Pyrroles/blood; Quinazolines/blood; Chromatography, High Pressure Liquid/standards; Drug Stability; Humans; Least-Squares Analysis; Pyrroles/chemistry; Pyrroles/metabolism; Quinazolines/chemistry; Quinazolines/metabolism; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry/methods

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrroles / Quinazolines / Chromatography, High Pressure Liquid Type of study: Diagnostic_studies Limits: Humans Language: En Journal: J Chromatogr B Analyt Technol Biomed Life Sci Journal subject: ENGENHARIA BIOMEDICA Year: 2012 Document type: Article Affiliation country: Switzerland Country of publication: Netherlands

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