Matrix metalloproteinase-10 is required for lung cancer stem cell maintenance, tumor initiation and metastatic potential.

Justilien, Verline; Regala, Roderick P; Tseng, I-Chu; Walsh, Michael P; Batra, Jyotica; Radisky, Evette S; Murray, Nicole R; Fields, Alan P

Justilien, Verline; Regala, Roderick P; Tseng, I-Chu; Walsh, Michael P; Batra, Jyotica; Radisky, Evette S; Murray, Nicole R; Fields, Alan P.

Affiliation

Justilien V; Department of Cancer Biology, Mayo Clinic College of Medicine, Jacksonville, Florida, United States of America.

PLoS One ; 7(4): e35040, 2012.

Article in En | MEDLINE | ID: mdl-22545096

Subject(s)

Gene Expression Regulation, Neoplastic; Lung Neoplasms/enzymology; Lung Neoplasms/genetics; Matrix Metalloproteinase 10/genetics; Matrix Metalloproteinase 10/metabolism; Neoplastic Stem Cells/enzymology; Animals; Cell Line, Tumor; Cell Transformation, Neoplastic/genetics; Cell Transformation, Neoplastic/metabolism; Cell Transformation, Neoplastic/pathology; Humans; Lung/enzymology; Lung/metabolism; Lung/pathology; Lung Neoplasms/pathology; Mice; Mice, Inbred C57BL; Neoplasm Metastasis/genetics; Neoplasm Metastasis/pathology; Neoplastic Stem Cells/metabolism; Neoplastic Stem Cells/pathology; Tumor Microenvironment

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Neoplastic Stem Cells / Gene Expression Regulation, Neoplastic / Matrix Metalloproteinase 10 / Lung Neoplasms Limits: Animals / Humans Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2012 Document type: Article Affiliation country: United States Country of publication: United States

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