Investigation of the binding pocket of human hematopoietic prostaglandin (PG) D2 synthase (hH-PGDS): a tale of two waters.

Trujillo, John I; Kiefer, James R; Huang, Wei; Day, Jacqueline E; Moon, Joseph; Jerome, Gina M; Bono, Christine P; Kornmeier, Christine M; Williams, Melanie L; Kuhn, Cyrille; Rennie, Glen R; Wynn, Thomas A; Carron, Christopher P; Thorarensen, Atli

Trujillo, John I; Kiefer, James R; Huang, Wei; Day, Jacqueline E; Moon, Joseph; Jerome, Gina M; Bono, Christine P; Kornmeier, Christine M; Williams, Melanie L; Kuhn, Cyrille; Rennie, Glen R; Wynn, Thomas A; Carron, Christopher P; Thorarensen, Atli.

Affiliation

Trujillo JI; Departments of Medicinal Chemistry, Pfizer Global Research and Development, Chesterfield, MO 63017, United States. john.i.trujillo@pfizer.com

Bioorg Med Chem Lett ; 22(11): 3795-9, 2012 Jun 01.

Article in En | MEDLINE | ID: mdl-22546671

Subject(s)

Anti-Allergic Agents/chemistry; Anti-Inflammatory Agents/chemistry; Enzyme Inhibitors/chemistry; Intramolecular Oxidoreductases/antagonists & inhibitors; Lipocalins/antagonists & inhibitors; Water/chemistry; Anti-Allergic Agents/chemical synthesis; Anti-Inflammatory Agents/chemical synthesis; Binding Sites; Computer Simulation; Crystallography, X-Ray; Enzyme Inhibitors/chemical synthesis; Humans; Intramolecular Oxidoreductases/metabolism; Isoquinolines/chemistry; Lipocalins/metabolism; Naphthalenes/chemistry; Protein Structure, Tertiary

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Water / Anti-Allergic Agents / Intramolecular Oxidoreductases / Enzyme Inhibitors / Lipocalins / Anti-Inflammatory Agents Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2012 Document type: Article Affiliation country: United States Country of publication: United kingdom

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