Plasma leakage through glomerular basement membrane ruptures triggers the proliferation of parietal epithelial cells and crescent formation in non-inflammatory glomerular injury.

Ryu, Mi; Migliorini, Adriana; Miosge, Nicolai; Gross, Oliver; Shankland, Stuart; Brinkkoetter, Paul T; Hagmann, Henning; Romagnani, Paola; Liapis, Helen; Anders, Hans-Joachim

Ryu, Mi; Migliorini, Adriana; Miosge, Nicolai; Gross, Oliver; Shankland, Stuart; Brinkkoetter, Paul T; Hagmann, Henning; Romagnani, Paola; Liapis, Helen; Anders, Hans-Joachim.

Affiliation

Ryu M; Nephrologisches Zentrum, Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Germany.

J Pathol ; 228(4): 482-94, 2012 Dec.

Article in En | MEDLINE | ID: mdl-22553158

Subject(s)

Glomerular Basement Membrane/metabolism; Glomerular Basement Membrane/pathology; Nephritis, Hereditary/metabolism; Nephritis, Hereditary/pathology; Adolescent; Adult; Animals; Autoantigens/genetics; Blood Proteins/pharmacology; Cell Line, Transformed; Cell Polarity/physiology; Cell Proliferation/drug effects; Collagen Type IV/genetics; Disease Models, Animal; Disease Progression; Epithelial Cells/metabolism; Epithelial Cells/pathology; Female; Fibrinolysis/drug effects; Humans; Male; Mice, 129 Strain; Mice, Knockout; Nephritis, Hereditary/prevention & control; Primary Cell Culture; Urokinase-Type Plasminogen Activator/pharmacology; Wound Healing/physiology

Key words

Alport; chronic kidney disease; collagen; crescent; glomerulosclerosis; parietal epithelial cells

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Glomerular Basement Membrane / Nephritis, Hereditary Type of study: Prognostic_studies Limits: Adolescent / Adult / Animals / Female / Humans / Male Language: En Journal: J Pathol Year: 2012 Document type: Article Affiliation country: Germany Country of publication: United kingdom

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